Cajun Chicken Alfredo Pasta

Featured in: Everyday Treats

This dish features tender chicken breasts coated in Cajun seasoning, cooked to perfection, and paired with al dente fettuccine tossed in a smooth Velveeta cheese sauce. The sauce blends butter, garlic, heavy cream, and Parmesan, with a touch of cayenne for subtle heat. Garnished with fresh parsley and extra Parmesan, it offers a creamy, spicy Southern-inspired flavor perfect for a comforting main course. Simple to prepare, it can be enhanced by adding bell peppers or mushrooms for additional color and taste.

Updated on Sun, 23 Nov 2025 10:25:00 GMT
Tender Cajun Chicken Alfredo Fettuccine pasta with creamy Velveeta sauce, garnished with fresh parsley. Save to Pinterest
Tender Cajun Chicken Alfredo Fettuccine pasta with creamy Velveeta sauce, garnished with fresh parsley. | flourhollow.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This dish quickly became a family favorite when I first made it for a casual dinner party.

Ingredients

  • Chicken: 2 large boneless, skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional for extra heat), Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside, reserving ½ cup pasta water.
Step 2:
While the pasta cooks, pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet, heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side, or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken, let rest 5 minutes, then slice thinly.
Step 4:
In the same skillet, reduce heat to medium. Add butter and garlic—sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring often until melted and smooth.
Step 6:
Add Parmesan cheese, black pepper, and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick, add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
A close-up of Cajun Chicken Alfredo Fettuccine, a comforting dish with a rich cheese sauce. Save to Pinterest
A close-up of Cajun Chicken Alfredo Fettuccine, a comforting dish with a rich cheese sauce. | flourhollow.com

This recipe often brings my family together around the table for a cozy meal filled with laughter and shared stories.

Notes

Add sautéed bell peppers or mushrooms for extra flavor and color. Pairs well with a crisp green salad and a chilled Chardonnay.

Required Tools

Large pot, large skillet, knife and cutting board, tongs or pasta fork, measuring cups and spoons.

Allergen Information

Contains milk/dairy (Velveeta, Parmesan, cream, butter). Contains wheat (fettuccine). Contains chicken. Those with allergies should check ingredient labels for hidden allergens.

Warm, flavorful Cajun Chicken Alfredo Fettuccine featuring perfectly cooked pasta and savory chicken. Save to Pinterest
Warm, flavorful Cajun Chicken Alfredo Fettuccine featuring perfectly cooked pasta and savory chicken. | flourhollow.com

This Cajun Chicken Alfredo packs bold flavors while remaining easy to prepare, making it a perfect weeknight dinner.

Recipe FAQs

How do I ensure the chicken stays tender?

Pat the chicken dry before seasoning and avoid overcooking. Cook until the internal temperature reaches 165°F (74°C) for juicy, tender meat.

Can I adjust the spiciness of the dish?

Yes, modify the amount of Cajun seasoning and cayenne pepper to suit your preferred heat level.

What’s the best way to prevent the sauce from thickening too much?

If the sauce becomes too thick, stir in reserved pasta water gradually until the desired consistency is reached.

Can I substitute Velveeta cheese with another type?

Velveeta provides a smooth melt, but cream cheese or mild cheddar can be alternatives, although the texture may vary.

How do I keep the fettuccine from sticking together?

Cook pasta in plenty of salted boiling water until al dente, then drain and toss immediately in the sauce to prevent sticking.

Cajun Chicken Alfredo Pasta

Tender Cajun chicken paired with creamy Velveeta sauce and fettuccine for a rich, flavorful meal.

Prep Duration
15 mins
Cook Duration
25 mins
Overall Time
40 mins
Created by Megan Turner


Skill Level Easy

Cuisine Type American (Cajun-inspired)

Serves 4 Servings Count

Dietary Details None specified

Ingredient List

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Steps

Step 01

Cook the Fettuccine: Bring a large pot of salted water to a boil. Cook fettuccine according to package instructions until al dente. Drain, reserving ½ cup pasta water, and set pasta aside.

Step 02

Prepare the Chicken: Pat chicken breasts dry and coat both sides evenly with Cajun seasoning.

Step 03

Sear the Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden and internal temperature reaches 165°F (74°C). Remove from skillet and let rest for 5 minutes before slicing thinly.

Step 04

Sauté Garlic in Butter: Reduce heat to medium and add butter to the same skillet, followed by minced garlic. Sauté for 1 minute until fragrant.

Step 05

Prepare Velveeta Sauce: Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes and stir frequently until fully melted and sauce is smooth.

Step 06

Season the Sauce: Incorporate grated Parmesan, black pepper, cayenne pepper if using, and salt to taste. Adjust thickness by gradually adding reserved pasta water as needed.

Step 07

Combine Pasta with Sauce: Toss cooked fettuccine in the sauce until evenly coated.

Step 08

Plate and Garnish: Divide pasta among serving plates, top with sliced Cajun chicken, and garnish with chopped parsley and additional Parmesan if desired.

Equipment Needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Info

Review every ingredient to spot potential allergens. Always confirm with your healthcare provider if unsure.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter).
  • Contains wheat (fettuccine).
  • Contains chicken.

Nutrition Breakdown (per serving)

Nutrition details are for reference and can't substitute for professional advice.
  • Caloric Value: 670
  • Fat content: 32 g
  • Carbohydrates: 57 g
  • Protein Amount: 41 g